Lower Keys, FL Vacation Rentals

Compare 131 vacation rentals.
USA > Florida > Lower Keys, FL

Make Lower Keys, FL your next getaway

When you’re looking for that perfect Florida Keys vacation rental, be sure to browse our Lower Keys beach houses and condos. Spanning the length of the legendary Overseas Highway, the Lower Keys area begins around Marathon and stretches to the southwest all the way to Key West. Whether you’re visiting for a weekend or the entire winter, a visit to a Lower Keys vacation rental guarantees tropical bliss.

Explore Lower Keys, FL house rentals, condo rentals, studios, and more

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House rentals

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Condo rentals

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Studios

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Popular amenities for Lower Keys, FL vacation rentals

Popular
Dog-friendly Hot tub Internet
Windward Isle
2 Bedroom | 1 Bath | Sleeps 6

Windward Isle - Key West, FL

$624 avg / night
4.32 (41)
Truman @ Duval - Unit F
0 Bedroom | 1 Bath | Sleeps 2

Truman @ Duval - Unit F - Key West, FL

$342 avg / night
4.23 (31)
Sunrise Suites - Barbados Suite 204
2 Bedroom | 2 Bath | Sleeps 6

Sunrise Suites - Barbados Suite 204 - Key West, FL

$512 avg / night
4.2 (132)
Sunrise Suites - Panama Suite 310
2 Bedroom | 2 Bath | Sleeps 6

Sunrise Suites - Panama Suite 310 - Key West, FL

$445 avg / night
4.53 (133)
Truman @ Duval - Studio A
0 Bedroom | 1 Bath | Sleeps 2

Truman @ Duval - Studio A - Key West, FL

$365 avg / night
4.4 (48)

View 126 more homes

Recent Lower Keys, FL guest reviews

Just finished a quick stay, and enjoyed everything. Love the access to Duval Street. They’ve done a great job with the house and we plan to stay again but longer this time.
Kevin C. | Jan 2025
What a wonderful spot for a couple to spend their downtime to recharge while out and about in Key West. It was a perfect spot to take a nap, whip up a meal, or just relax in the A/C while reading a book. This property sits back with a private, gated entry which makes it feel more secluded and private. Wonderful spot for two to enjoy their time together.
James F. | Jan 2025
The home was beautiful and accurate in description and photos. Quiet residential area with its location basically in the center of Old Town which makes it very walkable to any point in the area. Will definitely look into staying here again the next time we want to spend a few days in Key West.
Gary M. | Jan 2025
Lower Keys, FL vacation rental FAQ

Yes, 53 of our Lower Keys, FL homes allow dogs—so feel free to bring Fido along. (Just make sure to check individual home listings for any limits on the number and size of dogs they allow).

Browse dog-friendly homes >

Yes. 131 of our Lower Keys, FL vacation rentals have internet access, so you can stay connected throughout your trip.

Browse homes with internet access >


Some of the most popular amenities in our Lower Keys, FL vacation rentals include:

Our standard check-in time is 4:00 p.m., and the check-out time is 10:00 a.m. Some exceptions apply—after you book, you’ll find check-in and check-out details in the Vacasa guest app or your Trip Manager.

Absolutely. Our local Lower Keys, FL team includes professional housekeepers who care for all our homes here. They’ll clean thoroughly and restock amenities, so everything is ready for your arrival—and all you have to do is settle in and relax.

Learn more about Vacasa Premium Clean >

No worries, plans change. Read over our cancellation policy for more information. And if you currently have a Vacasa reservation for Lower Keys, FL, log in to Trip Manager to see options available for your specific trip.

Book confidently. Stay comfortably.

Vacasa Guest Value Prop icon: 24-7
24/7 guest service
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Seamless check-in
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Professional cleaning


Marathon and Key Colony Beach: the gateway to the Lower Keys


The town of Marathon, which technically encompasses several keys, is one of the most popular destinations in the Florida Keys. Key Colony Beach, the hub of Marathon, is home to several beautiful stretches of shoreline, as well as plenty of docks, restaurants, and luxurious vacation rentals to choose from. Like everywhere in the Lower Keys, the fishing and snorkeling surrounding Marathon are superb, so don’t be afraid to get out on the waves!

Cudjoe Key, the Torch Keys, and Sugarloaf Key


Cross the Seven Mile Bridge, and you’ll find the hidden gems of the Lower Keys: the Torch Keys, Cudjoe Key, and Sugarloaf Key. These less populous parts of the Keys are home to some of our most secluded and beautiful Florida Keys vacation rentals, some of which are beachfront---an amenity in hot demand in the Lower Keys. Find your own little corner of paradise here, and you’re just a short car trip away from the hustle and bustle of Key West or Marathon.

Key West: the southern end of the Lower Keys


Colloquially recognized as the United States’ Southernmost Point, Key West is a historic and beautiful spot for a Keys getaway. Many of our Key West vacation rentals boast private pools, luxurious interiors, spacious patios, and rich history. Duval Street is the hub of most of the town’s action, with plenty of shopping, dining, and entertainment choices. Book a fishing excursion or sailing charter and enjoy the crystal-blue waters that surround you, or rent snorkeling gear and experience the area’s renowned coral reefs. A Key West vacation rental is the perfect place to spend the whole winter---snowbirds are welcome!

No matter where you're headed in the Lower Keys, we have a picturesque vacation home waiting for you. Book today!